七天出诊信息 | 星期一 | 星期二 | 星期三 | 星期四 | 星期五 | 星期六 | 星期日 |
---|
张兆旭,男,神经病学博士学位,神经免疫专业组带头人、罕见疑难病专业组带头人。兼任中国卒中学会神经免疫学分会委员,中国老年医学会心脑血管病分会委员、中国卒中学会血管认知障碍委员会委员、中华预防医学会慢性疾病学会委员、中国阿尔茨海默病防治协会委员、北京医学会心脏心理学会委员、北京市神经病学会理事、国家卫健委脑卒中防治工程青年专家委员会委员。 主持国家自然科学基金及北京市课题3项;应用单细胞测序创新性研究重症肌无力患者骨髓造血系统上游的干细胞发生活化情况,阐明了重症肌无力发病和复发机制,更好的指导了临床治疗。以第一(通讯)作者发表国内外期刊论文60篇,其中SCI收录36余篇;主编专著《痴呆诊疗和预防》人民卫生出版社(55万字)、参编专著《血管性痴呆》、《阿尔茨海默病的诊断与治疗》;“敷贴式局部亚低温治疗急性大面积脑梗死”获得教育部科技进步一等奖1项(第三)。“复智力散治疗阿尔茨海默病机制研究”获得教育部科技进步一等奖1项(第二)。
1. Zhang, Z.;Bi, M.; Tong, S.;;Ma, Q.; Zhang, S.; Luo, Z.; Zhang, Y.; Li, X.; Wang, D., Changes in cerebral glucose metabolism in patients with mild-to-moderate Alzheimer's disease: a pilot study with the Chinese herbal medicine fuzhisan. Neurosci Lett 2011, 501 (1), 35-40. 2.Zhang ZX, Zhao RP, Wang DS, Li YB.Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. Neurochem Res. 2016 Nov;41(11):3074-3082. 3.Zhang ZX, Zhao RP, Wang DS, Wang AN.Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11month old APP/PS1 transgenic mice: A Western blot study.Exp Gerontol. 2016 Nov;84:88-95. 4.Zhang, Z.; Zhao, R.; Qi, J.; Wen, S.; Tang, Y.; Wang, D., Inhibition of glycogen synthase kinase-3beta by Angelica sinensis extract decreases beta-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. J Neurosci Res 2011, 89 (3), 437-47. 5. Zhang, Z.; Zhao, R.; Song, Y.; Wang, D.; Qi, J.; Wen, S., Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3beta pathway in ginsenoside Rb1's attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation. J Ethnopharmacol 2011, 133 (3), 1109-16. 6.Zhang, Z.; Zhao, R.; Tang, Y.; Wen, S.; Wang, D.; Qi, J., Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons. Neurochem Res 2011, 36 (5), 801-11. 7.Zhang ZX, Li YB, Zhao RP.Epigallocatechin Gallate Attenuates β-Amyloid Generation and Oxidative Stress Involvement of PPARγ in N2a/APP695 Cells.Neurochem Res. 2017 Feb;42(2):468-480. 8.《痴呆诊疗及预防》(55万字),人民卫生出版社,2016年,主编。